4-1BB

4-1BB, also known as CD137, belongs to the TNF-receptor superfamily. It is expressed by T-cells and, upon binding to the 4-1BB ligand (known as 4-1BBL or CD137L) on antigen presenting cells, promotes T-cell proliferation and survival. Since the 4-1BB ligand is expressed by various carcinoma cells, blocking the interaction between 4-1BB and 4-1BBL is investigated as a means of treating cancer. 4-1BB is also studied by researchers investigating autoimmune diseases such as collagen-induced arthritis (CIA), multiple sclerosis and systemic lupus erythematosus (SLE).

4-1BB related antibodies from preferred suppliers:

• BE0110 - InVivoMAb anti-mouse 4-1BBL (CD137L) - TKS-1 (clone no.) monoclonal antibody reacts with mouse 4-1BB ligand (4-1BBL), a type II transmembrane glycoprotein also known as CD137L.
• BE0169 - InVivoMAb anti-mouse 4-1BB (CD137) -  LOB12.3 (clone no.) monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member is also known as CD137.
• BE0239 - InVivoMAb anti-mouse 4-1BB (CD137) - The 3H3 (clone no.) monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member is also known as CD137. 
• BE0296 - InVivoMAb anti-mouse 4-1BB (CD137) - The 17B5 (clone no.) monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member is also known as CD137.
• TA328255 - TNFSF9 Rabbit Polyclonal Antibody - Produced from sera of rabbits pre-immunized with highly pure recombinant Human 4-1BBL. Anti-Human 4-1BBL specific antibody was purified by affinity chromatography employing immobilized Human 4-1BBL matrix.

Below are more purified version:

for more information on the differences between InVivoMAb and InVivoPlus please click HERE!

• BP0169 - InVivoPlus anti-mouse 4-1BB (CD137) - LOB12.3 (clone no.) monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member is also known as CD137.
• BP0239 - InVivoPlus anti-mouse 4-1BB (CD137) - 3H3 (clone no.) monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member is also known as CD137.

4-1BB related proteins from preferred suppliers:

• 41B-C52H4 - Cynomolgus / Rhesus macaque 4-1BB / TNFRSF9 Protein, His Tag - is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # XP_005544945.1). In the region Leu 24 - Gln 186, the AA sequence of Cynomolgus and Rhesus macaque 4-1BB are homologus.

• 41B-R52H9 - Rabbit 4-1BB / TNFRSF9 Protein, His Tag - is expressed from human 293 cells (HEK293). It contains AA Val 29 - Ile 191 (Accession # G1SHD7-1).

• 41B-M5258 - Mouse 4-1BB /TNFRSF9 Protein, Fc Tag - is expressed from human 293 cells (HEK293). It contains AA Val 24 - Leu 211 (Accession # NP_001070976).

• 41B-H5258 - Human 4-1BB / TNFRSF9 Protein, Fc Tag - is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gln 186 (Accession # NP_001552.2).

• 41B-H5256 - Human 4-1BB / TNFRSF9 Protein, Mouse IgG2a Fc Tag, low endotoxin - is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # Q07011-1). This protein carries a mouse IgG2a Fc tag at the C-terminus.

4-1BB related conjugated proteins:

• 41B-H82E3 - Biotinylated Human 4-1BB / TNFRSF9 Protein, Avitag™, His Tag - is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # NP_001552.2). This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag.

• 41B-H82F7 - Biotinylated Human 4-1BB /TNFRSF9 Protein, Fc,Avitag™ -  is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # NP_001552.2). This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™).

4-1BB related ELISA kits from preferred suppliers:

• ARG81801 - Human CD137 ELISA Kit - is an Enzyme immunoassay kit for the quantification of human CD137 in serum, plasma (heparin, EDTA) and cell culture supernatants.

• ARG81820 - Mouse CD137 ELISA Kit -  is an Enzyme immunoassay kit for the quantification of mouse CD137 in serum, plasma (heparin, EDTA) and cell culture supernatants.

4-1BB related Cell Lines from preferred supplier:

• M00568 - CHO-K1/mouse 4-1BB Stable Cell Line - (Academic Discount Available) High protein expression at the cell surface validated by FACS. Stable cell lines for increased reliability and reproducibility (over 15 passages). Ready to use hot targets, saving 3-5 months of drug discovery program. For Binding Assay.